Having commenced operations in 2006, Aquinox Pharmaceuticals Inc. is a privately-held pharmaceutical company developing targeted small molecule therapeutics for the treatment of cancer and inflammatory disease. The Company has a strong intellectual property portfolio and library of pre-clinical drug candidates that target a unique biochemical enzyme called "SHIP" (SH2-containing inositol phosphatase) which regulates the PI3 kinase (PI3K) pathway. Outstanding technology coupled with an exceptional management team and a recently completed US $14.5 million financing make it a very exciting time to seize this wonderful opportunity.

We are currently seeking a Research Associate in Medicinal Chemistry. The successful candidate will be responsible for the design and synthesis of novel pharmacologically active compounds using organic synthetic techniques.

Responsibilities will include, but are not limited to, the following activities:

• Design and execute scientific experiments with minimal supervision.
• Perform multi-step synthesis, compound purification and structural characterization.
• Optimize lead compounds and synthetic routes.
• Perform scale-up of intermediates and final target molecules.
• Maintain R&D laboratory notebook according to established guidelines.
• Data reduction and presentation.

To be successful in this role, you will have the following qualifications and experience:

• B.Sc. in Organic Chemistr or related field with 5-10 years of experience or relevant Masters degree with 3-5 years experience.
• Understanding of multistep organic chemistry including protecting group strategies.
• Milligram- and gram-scale synthesis using air and light sensitive reagents.
• Experience with chromatographic methods for the purification of compounds.
• Ability to use spectroscopic techniques including NMR, MS, etc. and spectral interpretation to assign/confirm chemical structure.
• Computer proficiency including knowledge of ChemDraw
• Ability to use the chemical literature and computer searching techniques to plan, solve and execute on the synthesis of target compounds
• Effective communication skills, strong interpersonal and organizational skills.
• Ability to work independently as well as in a team environment is essential.

Interested candidates are invited to forward their resume and cover letters to careers@aqxpharma.com. Please use the title of the position as the subject line and indicate where you saw this posting. Aquinox would like to thank all interested applicants for their interest; however, only those chosen for an interview will be contacted.