Review on PI3K pathway and cancer drug discovery
Hennessy, B. T., Smith, D. L., Ram, P. T., Lu, Y., and Mills, G. B. (2005). Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4, 988-1004.
Cully, M., You, H., Levine, A. J., and Mak, T. W. (2006). Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6, 184-192.
Reviews on SHIP
Rauh, M. J., Sly, L. M., Kalesnikoff, J., Hughes, M. R., Cao, L. P., Lam, V., and Krystal, G. (2004). The role of SHIP1 in macrophage programming and activation. Biochem Soc Trans 32, 785-788.
March, M. E., and Ravichandran, K. (2002). Regulation of the immune response by SHIP. Semin Immunol 14, 37-47.
Kalesnikoff, J., Lam, V., and Krystal, G. (2002). SHIP represses mast cell activation and reveals that IgE alone triggers signaling pathways which enhance normal mast cell survival. Mol Immunol 38, 1201-1206.
Chemistry paper on Aquinox compounds and analogues
Yang, L., Williams, D. E., Mui, A., Ong, C., Krystal, G., van Soest, R., and Andersen, R. J. (2005). Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP. Org Lett 7, 1073-1076.
Selected Papers on SHIP
Helgason, C. D., Damen, J. E., Rosten, P., Grewal, R., Sorensen, P., Chappel, S. M., Borowski, A., Jirik, F., Krystal, G., and Humphries, R. K. (1998). Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev 12, 1610-1620.
Rauh, M. J., Ho, V., Pereira, C., Sham, A., Sly, L. M., Lam, V., Huxham, L., Minchinton, A. I., Mui, A., and Krystal, G. (2005). SHIP represses the generation of alternatively activated macrophages. Immunity 23, 361-374.
Sly, L. M., Rauh, M. J., Kalesnikoff, J., Song, C. H., and Krystal, G. (2004). LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity 21, 227-239.
Huber, M., Helgason, C. D., Damen, J. E., Liu, L., Humphries, R. K., and Krystal, G. (1998). The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A 95, 11330-11335.