Scientist, Translational Biology

About Aquinox:

Aquinox Pharmaceuticals, Inc. is a late clinical-stage pharmaceutical company discovering and developing targeted therapeutics in disease areas of inflammation and immuno-oncology. Our primary focus is anti-inflammatory product candidates targeting SH2-containing inositol-5′-phosphatase 1, or SHIP1, which is a key regulator of an important cellular signaling pathway in immune cells, known as the PI3K pathway. Our lead product candidate, AQX-1125, is a small molecule activator of SHIP1 suitable for oral, once daily dosing. Having successfully completed multiple preclinical studies and seven clinical trials with AQX-1125, we are now in a Phase 3 program with our lead indication of interstitial cystitis/bladder pain syndrome (IC/BPS). Other indications are under consideration for future investigation. Aquinox has a broad intellectual property portfolio and pipeline of preclinical drug candidates that activate SHIP1.

We are a focused team, achieving our goals through our values based culture. Our people are highly results-oriented, proactive and collaborative.

Aquinox is publicly traded on NASDAQ and has offices in Vancouver, BC, Canada and in San Bruno, CA, USA.

The Location of Position:

The Scientist, Translational Biology position will be located in our Vancouver, BC, office.

The Opportunity:

Reporting to the Senior Manager, Translational Biology, the Scientist will be involved with leading activities around the biology and pharmacology of current and new lead candidates.

Specifically, the Scientist will:

  • Independently develop, design, troubleshoot and implement:
    • In vitro and in vivo studies
    • New models to support project advancement as necessary
  • Will assist in model selection and evaluation, benchmarking and standardization of models and design of PK/PD studies
  • Integrate and interpret available biological data, in collaboration with the Medicinal Chemistry team for design of new molecules
  • Work with scientists’ cross-functionally to ensure high scientific quality of all in vivo and in vitro studies
  • Identify CROs or other collaborators that could enable models or apply novel expertise in support of program advancement
  • Collaborate, monitor and report on CRO-based studies
  • Write and review reports and assist in the generation of materials for publication

What you bring:

  • PhD degree in immunology, oncology, neurobiology or related field; 2+ years of experience in biotechnology specifically related to in vitro and in vivo studies strongly preferred
  • Be self-driven and able to contribute significantly on hypothesis, experimental design, interpreting primary pharmacological data, providing input, communicating results and report writing
  • Manage external relations with CROs to achieve objectives
  • Develop alternatives and solutions for a range of complex scientific problems. Solutions require creativity, critical thinking and collaboration, considering a broad range of potential impacts
  • Excellent written, verbal communication and interpersonal skills to collaborate with internal and external partners in a matrix environment
  • Attention to detail and strong documentation experience is required
  • Ability to work well with a wide range of functional groups and ability to work independently

Interested candidates are invited to forward their resume and cover letter to, indicating why you feel you are a fit for the Scientist, Translational Biology role at Aquinox Pharmaceuticals, Inc.

We thank all applicants for their interest; only those chosen for an interview will be contacted.